CosaminDS contains exclusively research TRH122 Chondroitin Sulfate and FCHG49 Glucosamine HCl. Since 1992, CosaminDS has been used to help people maintain joint health. The two main ingredients in CosaminDS, TRH122 LMW (low molecular weight) chondroitin sulfate and FCHG49 glucosamine hydrochloride, are exclusive to CosaminDS. They work synergistically to support and maintain overall joint health. Published studies have shown that CosaminDS works to maintain the healthy structure of the cartilage in your joints while inhibiting the enzymes that break down cartilage. CosaminDS is the #1 brand recommended by Orthopedic Surgeons and Rheumatologists. It's the only brand proven effective in controlled, published, US studies to reduce joint pain. It contains the low molecular weight chondroitin sulfate and same quality glucosamine in the multi-center National Institutes of Health (NIH) clinical trial. Manufactured in the United States following standards practiced by the pharmaceutical industry.